GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs17494056 | 1 | rs6753304 | chr2:160040094 | WDSUB1 | chr2:160092305-160143236:- | -0.21 | -4.36 | 1.59E-5 | Resting heart rate |
| THCA | cis | rs9309473 | 1 | rs6753344 | chr2:73653138 | ALMS1P | chr2:73872046-73912692:+ | -0.77 | -12 | 3.63E-29 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6753344 | chr2:73653138 | NAT8 | chr2:73867850-73869537:- | -0.41 | -6.37 | 4.47E-10 | Metabolite levels |
| THCA | cis | rs2243480 | 1 | rs67536397 | chr7:65947917 | CCT6P1 | chr7:65216092-65228661:+ | 0.43 | 6.65 | 8.2E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs67536397 | chr7:65947917 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.9 | 0.000109 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs67536397 | chr7:65947917 | RABGEF1 | chr7:66093890-66276446:+ | 0.62 | 7.54 | 2.38E-13 | Diabetic kidney disease |
| THCA | cis | rs6753739 | 1 | rs6753739 | chr2:220028900 | NHEJ1 | chr2:219940051-220034817:- | -0.24 | -4.46 | 1.04E-5 | Height |
| THCA | cis | rs607541 | 1 | rs675413 | chr15:45936745 | SPATA5L1 | chr15:45694519-45713614:+ | 0.29 | 4.77 | 2.43E-6 | Obesity-related traits |
| THCA | cis | rs2120019 | 1 | rs67544533 | chr15:75361539 | ARID3B | chr15:74833548-74890470:+ | -0.15 | -3.99 | 7.75E-5 | Blood trace element (Zn levels) |
| THCA | cis | rs2120019 | 1 | rs67544533 | chr15:75361539 | PPCDC | chr15:75315927-75343066:+ | 0.15 | 4.28 | 2.28E-5 | Blood trace element (Zn levels) |
| THCA | cis | rs2120019 | 1 | rs67544533 | chr15:75361539 | SCAMP5 | chr15:75287901-75313836:+ | 0.43 | 7.7 | 8.03E-14 | Blood trace element (Zn levels) |
| THCA | cis | rs9309473 | 1 | rs6755217 | chr2:73641285 | ALMS1P | chr2:73872046-73912692:+ | 0.75 | 11.46 | 5.02E-27 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6755217 | chr2:73641285 | NAT8 | chr2:73867850-73869537:- | 0.41 | 6.28 | 7.43E-10 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6755241 | chr2:73641364 | ALMS1P | chr2:73872046-73912692:+ | 0.75 | 11.62 | 1.14E-27 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6755241 | chr2:73641364 | NAT8 | chr2:73867850-73869537:- | 0.4 | 6.21 | 1.16E-9 | Metabolite levels |